News and discussion on Green Tea (EGCG)

Green tea is a drink made from the steamed and dried leaves of the Camellia sinesis plant, a shrub native to Asia. Green Tea has been used as a medicine in China for about 4000 years. There are four primary polyphenols in green tea & they are often collectively known as catechins. Epigallocatechin gallate (EGCG) is one of most powerful polyphenol and it has anti-oxidant properties.

Thursday, June 22, 2006

How Can Epigallocatechin Gallate from Green Tea Prevent HIV-1 Infection?

Possible inhibitors preventing human immunodeficiency virus type 1 (HIV-1) entry into the cells are recognized as hopeful next-generation anti-HIV-1 drugs. It is highly desirable to develop a potent inhibitor blocking binding of glycoprotein CD4 of the cell with glycoprotein gp120 of HIV-1, because the gp120-CD4 binding is the initial step of HIV-1 entry into the cells. It has been recently reported that (-)-epigallocatechin gallate (EGCG) from green tea is an inhibitor blocking gp120-CD4 binding.

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EGCG ABSTRACT

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